Subretinal fluid overlying a drusenoid pigment epithelial detachment in an eye with dry age-related macular degeneration
DOI:
https://doi.org/10.62856/djcro.v10.72Keywords:
age-related macular degeneration, subretinal fluid, drusenoid pigment epithelial detachmentAbstract
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness worldwide. It is generally classified into two forms: dry (non-neovascular) AMD and wet (neovascular) AMD. Wet AMD is typically characterized by subretinal fluid (SRF) resulting from choroidal neovascularization. We present a rare case of dry AMD with a drusenoid pigment epithelial detachment (PED) and overlying SRF, mimicking wet AMD. This case demonstrates that SRF can also occur in eyes with dry AMD, especially in the presence of a large drusenoid PED. Possible mechanisms include mechanical stress from confluent drusen, the presence of an avascular serous PED, and age-related retinal pigment epithelium dysfunction. Previous studies have reported similar cases with a low rate of progression to wet AMD. This case emphasizes the diagnostic challenge of relying solely on SRF to identify wet AMD and highlights the importance of accurate classification to avoid unnecessary intravitreal anti-VEGF injections.
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